PCOS Series (Part 3): The Self-Perpetuating Engine
In Parts 1 and 2, we broke down the two main problems in PCOS: insulin resistance and the LH/FSH hormone imbalance. Now let’s connect the dots to show how they create a cycle that keeps itself running.
The Loop: How Everything Connects
These two problems—insulin and hormones—don’t work separately. They feed into each other and create a loop that, once it starts, can keep going on its own:
- Insulin Resistance leads to High Insulin.
- High Insulin and High LH lead to High Testosterone.
- High Testosterone messes up the brain signals, making even more LH.
- High Testosterone also causes belly fat, which makes Insulin Resistance worse.
This is the PCOS engine. It’s a loop where each part makes the other parts worse. The insulin problem drives the hormone problem, and the hormone problem feeds back to make the insulin problem worse.
This is why simple solutions don’t work. You can’t just exercise more or take a pill and expect it to fix everything. You have to attack the whole system.
Key Takeaways
- A Loop That Feeds Itself: Insulin resistance and hormone problems aren’t separate—they create a cycle that keeps itself going.
- Testosterone Makes Insulin Worse: The hormone symptoms aren’t just side effects; they actively make the insulin problem worse.
- You Must Break the Whole System: You can’t fix one part and ignore the others. The entire cycle has to be stopped.
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References
[1] Rosenfield, R. L., & Ehrmann, D. A. (2016). The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocrine Reviews, 37(5), 467–520. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045492/
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